N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide
- Product Name
- N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide
- CAS No.
- 294623-49-7
- Chemical Name
- N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide
- Synonyms
- L 006235;I-006,235;L-006235;L 006235;L006235;N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamide;N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide;N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide;Benzamide, N-[1-[[(cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]-;L-235,L-006235,collagen,bone,loss,L 235,resorption,L006235,Inhibitor,inhibit,degradation,Cathepsin,L235
- CBNumber
- CB02518862
- Molecular Formula
- C24H30N6O2S
- Formula Weight
- 466.6
- MOL File
- 294623-49-7.mol
N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- <46.66mg/ml in DMSO
- form
- solid
- pka
- 12.07±0.20(Predicted)
- color
- White
N-Bromosuccinimide Price
- Product number
- 28843
- Product name
- L-006,235
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 28843
- Product name
- L-006,235
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 28843
- Product name
- L-006,235
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 28843
- Product name
- L-006,235
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 3066
- Product name
- L006235
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $256
- Updated
- 2021/12/16
N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide Chemical Properties,Usage,Production
Uses
L 006235 is a cathepsin K inhibitor, which displays greater than 4000-fold selectivity against the lysosomal/endosomal antitargets cathepsin B, L, and S.
Biological Activity
l-006235 is a potent and selective inhibitor of cathepsin k.
in vitro
after dilution of l-006235 to 0.05 nm, the cathepsin k enzyme activity was initially inhibited, but slowly recovered with a first-order rate constant of 0.023 s-1. the final steady-state enzyme activity was 80-90% that of control, suggesting the complete reversibility of the l-006235-cathepsin k complex. l-006235 was found to be not a substrate for the nitrilase activity of cat k [1].
in vivo
l-006235 was orally bioavailable in rats, with a terminal half-life of over 3 h. l-006235 was orally dosed in ovariectomized rhesus monkeys once per day for 7 days. results showed that collagen breakdown products were dose-dependently reduced by up to 76%. plasma concentrations of l-006235 above the bone resorption ic50 after 24 h indicated a correlation between functional cellular and in vivo assays. these findings suggested that the inhibition of collagen breakdown by cathepsin k inhibitors, such as l-006235, might be useful in osteoporosis and other indications involving bone resorption [1].
IC 50
0.25 nm
storage
Store at +4°C
References
[1] palmer jt,bryant c,wang dx et al. design and synthesis of tri-ring p3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin k. j med chem.2005 dec 1;48(24):7520-34.
N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide Suppliers
View Lastest Price from N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide manufacturers
- Product
- N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide 294623-49-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20